Clinical Studies

A Collection of Clinical Studies on the Effectiveness of Shock Wave Therapy on Chronic Ulcers (including Diabetic Foot Ulcer) and the Mechanism of Action of ESWT. 

  1. Yan X, Zeng B, Chai Y, Luo C, Li X. (2008) Improvement of Blood Flow, Expression of Nitric Oxide, and Vascular Endothelial Growth Factor by Low-Energy Shockwave therapy in Random-Pattern Skin Flap Model. Annals of Plastic Surgery, 61 (6), pp. 646-653.
  2. Krokowicz L, Cwykiel J, Klimczak A, Mielniczuk M, Siemionow M (2010) Pulsed Acoustic Cellular Treatment Induces Expression of Proangiogenic Factors and Chemokines in Muscle Flaps. Journal of Trauma, 69(6), pp. 1448-1456.
  3. De Sanctis MT, Belcaro G, Nikolaides AN, Cesarone MR, Incandela L, Marlinghaus E, Griffin M, Capodanno S, Ciccarelli R. (2000) Effects of Shock Waves on the Microcirculation in Critical Limb Ischemia. Angiology, 51(8:2), pp. 69-78.
  4. Wanner et al. (2011) Low-energy shock waves enhance the susceptibility of staphylococcal biofilms to antimicrobial agents in vitro. Journal of Bone and Joint Surgery, 93-B(6), pp. 824-827.
  5. Cwykiel JM, Klimczak A, Krokowicz L, Siemionow M. (2013) Pre- and Postischemic Pulsed Acoustic Cellular Expression Conditioning Modulates Expression of Inflammation Factors in Cremaster Ischemia/Reperfusion Injury Model. Microsurgery, 33(2), pp. 134-140.
  6. Davis TA, Stojadinovic A, Anam K, Amare M, Naik S, Peoples GE, Tadaki D, Elster EA (2009) Extracorporeal Shock Wave Therapy Suppresses the Early Proinflammatory Immune Response to a Severe Cutaneous Burn Injury. International Wound Journal, 6(1), pp. 11-21.
  7. Stojadinovic A, Elster E A, Anam K, Tadaki D, Amare M, Zins S, Davis TA (2008) Angiogenic response to Extracorporeal Shock Wave Treatment in Murine Skin Isografts. Angiogenesis, 11(4), pp. 369-80.
  8. Wang C-J, Ko J-Y, Kuo Y-R, Yang Y-J  (2011) Molecular Changes in Diabetic Foot Ulcers. Diabetes Research and Clinical Practice, 94(1), pp. 105-110.
  9. Wang C-J, Wang F-S, Yand KD (2004) Biological Mechanism of Musculoskeletal Shockwaves. International Society for Musculoskeletal Shockwave Therapy Newsletter, 1(1).
  10. Meirer R, Brunner A, Deibl M, Oehlbauer M, Piza-Katzer H, Kamelger FS (2007) Shock wave therapy reduces necrotic flap zones and induces VEGF expression in animal epigastric skin flap model. Journal of Reconstructive Microsurgery, 23(4), pp. 231-236.
  11. Meirer R, Heumer GM, Oehlbauer M, Wanner S, Piza-Katzer H, Kamelger FS (2007) Comparison of the effectiveness of gene therapy with vascular endothelial growth factor or shockwave therapy to reduce ischaemic necrosis in an epigastric skin flap model in rats. Journal of Plastic, Reconstructive and Aesthetic Surgery, 60(3), pp. 266-271.
  12. Huemer GM, Meirer R, Gurunluoglu R, Kamelger FS, Dunst KM, Wanner S, Piza-Katzer H (2005) Comparison of the Effectiveness of Gene Therapy with transforming growth factor-b or extracorporeal shock wave therapy to reduce ischemic necrosis in an epigastric skin flap model in rats. Wound Repair and Regeneration, 13(3), pp. 262-268.
  13. Saggini R, Figus A, Troccola A, Cocco V, Saggini A and Scuderi N (2008) Extracorporeal shock wave therapy for management of chronic ulcers in the lower extremities. Ultrasound in Medicine and Biology, 34(8), pp. 1261-1271.
  14. Data on File.